RESTYLANE® Portfolio of Hyaluronic Acid (HA) Fillers

With more than 40 million treatments completed worldwide and counting, the RESTYLANE line of hyaluronic acid (HA) dermal fillers is the broadest portfolio of fillers in the U.S. RESTYLANE is the only line of fillers with treatments FDA-approved for both the face and hands. The fillers work by smoothing away facial wrinkles and folds (Restylane, Restylane Lyft, Restylane Refyne, Restylane Defyne), enhancing lips (Restylane, Restylane Silk), smoothing lines around the mouth (Restylane Silk), adding lift and volume to the cheeks (Restylane Lyft), and reversing the signs of volume loss in the back of aging hands (Restylane Lyft).

RESTYLANE uses two types of technologies to deliver a natural and youthful-looking appearance. Certain RESTYLANE products are formulated with XpresHAn TechnologyTM, which are the only HA filler options proven to maintain natural facial expressions. Select RESTYLANE products are formulated with NASHA Technology, which creates a firmer gel texture that allows for precise injection, leading to a more pronounced lift and smoother skin. All RESTYLANE products deliver results that are natural-looking.

RESTYLANE is formulated with lidocaine, which reduces pain during injection and post-injection to improve the treatment experience.

Restylane Refyne and Defyne

Restylane Refyne and Restylane Defyne, introduced in 2017, are FDA-approved to smooth smile and laugh lines. They are the only fillers designed with Galderma’s unique manufacturing process, XpresHAn Technology™, which creates a smooth, injectable gel that can give the skin a natural, soft look, and is proven to maintain natural movement in the lower part of the face. Since the lower part of the face is constantly in motion, it’s important to use a filler that supports natural movement and facial expressions.

Both Restylane Refyne and Restylane Defyne have been used outside the U.S. under the name Emervel since 2011, so safety and efficacy are well-established with more than one million treatments worldwide. Results with Restylane Refyne and Restylane Defyne are clinically proven to last up to 12 months.

Restylane Lyft

Restylane Lyft is the first and only hyaluronic acid filler to be FDA-approved for both the face and hands – the midface/cheek area, nasolabial folds, marionette lines, oral commissures (lines at the corner of the mouth), and the back of the hands. Restylane Lyft restores volume to the cheeks and hands for a smoother, more youthful looking appearance. One of the most versatile products in the Restylane portfolio, Restylane Lyft, formerly known as Perlane, has been on the market for more than 10 years and has a proven track record of safety and efficacy. Results are clinically proven to last up to 18 months in the nasolabial folds, 12 months in the cheeks,
and up to 6 months in facial wrinkles and folds in the hands.

Restylane Lyft was voted one of 2019’s “Most Worth It” nonsurgical procedures by RealSelf, with 99 percent of patients rating the treatment as “Worth It.”

Restylane Silk

Restylane Silk was the first FDA-approved filler specifically designed for lip augmentation and the smoothing of wrinkles around the mouth. Restylane Silk is designed specifically to provide natural-looking results in these areas, due to its unique formulation. The lip area is the second most common treatment area on the face, and Restylane Silk provides a solution for patients interested in subtly enhancing this area.

Restylane Silk was approved in 2015 and has a proven safety record with results that last up to six months. In 2017, Restylane Silk also became the first and only lip filler FDA approved to be injected via cannula, a thin, flexible tube with a small opening that may help minimize patient bruising and downtime.


With more than 20 years of clinical legacy, Restylane was the world’s first hyaluronic acid filler. Restylane is FDA-approved to help correct moderate to severe facial wrinkles and folds, including the lines from the nose to the corners of the mouth (nasolabial folds) and the lines from the corners of the mouth to the chin (marionette lines), and for enhancement of the lips.



JUVÉDERM® is the #1 dermal filler collection in the world that offers 5 different products to meet your specific needs. Add volume to plump lips, smooth lines, or lift & contour cheeks—we have what you need to get the results you want.


Hyaluronic acid, or HA, is a naturally occurring substance that delivers volume to the skin. JUVÉDERM® is a long-lasting, non-surgical option that contains a modified form of HA. Fillers that include HA are a top choice for patients—over 90% of filler patients receive an HA dermal filler.


Looking for fuller lips? JUVÉDERM® Ultra XC can help plump lips while JUVÉDERM® VOLBELLA™ XC helps soften the appearance of vertical lip lines.


Smooth and soften the appearance of lines and wrinkles with JUVÉDERM® XC and JUVÉDERM® VOLLURE™ XC.


Age-related volume loss can cause cheeks to flatten and skin to sag. JUVÉDERM® VOLUMA™ XC helps add volume for lifting and contouring the cheek area.

Before & After

Juvederm Before & After 1
Juvederm Before & After 2
Juvederm Before & After 2
Juvederm Before & After 2

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